Genghis Khan
The worst version of myself
- Joined
- Apr 7, 2013
- Messages
- 44,993
BS will do.
Timestamped again!
BS will do.
I don't think it's Prescott, if they wanted to accommodate him above all else they'd have kept McCarthy (and Schottenheimer) or hired Moore.
I'm sure part of it is familiarity but the biggest reason they hired him in my opinion is that he's willing to go along with whatever nonsense the organization does (i.e. hiring Witten as the HC in waiting and spending all of FA playing with their assholes).
Hard to see him making it more than two seasons. Especially if they stick with their usual plan of attack for acquiring talent in the offseason.
Yep. They probably got to count Saleh as a DC Rooney Rule, but they need one more.
Translation: Eberflus will be the hire but they have to do some sham interviews first.
Jerry doesn’t have 10 years left.
Yep. They probably got to count Saleh as a DC Rooney Rule, but they need one more.
Yep, three year contract means he gets 3 years. Whatever the length is how long he will last.Depends on the length of the contract. I think it would have to be an abject disaster for Jerry to fire a coach.
You’re on a fuckin roll today, pal.Zombie cells, more scientifically known as senescent cells, are cells that have ceased to divide but do not die off as expected. Here's a bit more detail on what they are and their implications:
What Are Senescent Cells?
Cessation of Division: These cells stop dividing due to various stresses like DNA damage, telomere shortening, or oxidative stress. This cessation can occur as part of normal aging or in response to cellular damage.
Functionally Alive: Despite not proliferating, these cells remain metabolically active. They can change shape, size, and gene expression.
SASP (Senescence-Associated Secretory Phenotype): Senescent cells secrete a variety of proteins, including inflammatory cytokines, growth factors, and proteases. This secretion can affect the surrounding tissue environment, sometimes leading to chronic inflammation or promoting conditions conducive for cancer.
Role in Aging and Disease:
Aging: Senescent cells accumulate in tissues with age. They're believed to contribute to the aging process by altering tissue structure and function, leading to age-related diseases.
Disease: They've been implicated in conditions like cardiovascular diseases, diabetes, arthritis, and neurodegenerative disorders. There's also a link to cancer where they can either suppress tumor growth initially or, through SASP, promote tumor progression.
Therapeutic Potential: There's significant interest in targeting these cells for therapeutic purposes. Approaches include:
Senolytics: Drugs aimed at selectively killing senescent cells.
Senomorphics: Compounds that mitigate the negative effects of these cells without removing them.
Controversies and Research Directions:
Beneficial Roles: Not all effects of senescent cells are detrimental; they play roles in wound healing, embryonic development, and even potentially in preventing cancer by stopping damaged cells from proliferating.
Selective Elimination: One major challenge is distinguishing harmful senescent cells from those with beneficial roles to avoid unintended consequences in health therapies.
Long-term Effects: The long-term effects of senolytic treatments are still under investigation, with concerns about potential side effects or the body's response to the removal of these cells.
Research into senescent cells continues to grow, with implications for extending healthspan and treating various age-related diseases. However, the complexity of their role in biology means that while promising, the full therapeutic landscape is st
ill being explored.
Shows he is a major league suckass. Jerry’s perfect man for the job10 hours listening to the Jones’ talk is a violation of the Geneva Conventions.
At least Schottemheimer has proven his mental toughness.
Pretty much.
Translation: Eberflus will be the hire but they have to do some sham interviews first.