Keanu Neal would make sense if we used him as a pseudo-LB/safety hybrid. You'd still need a FS but you could keep Wilson on the field with him as basically interchangeable SS/LB's who can play the run and blitz.
Our base could be a 4-2-5 but two of those DB's are box safety/light LB's in today's game, then in dime you can take one of the LB's off the field and replace them with a CB or whatever.
It's a bit of a stretch but I think it could make a lot of sense, it'd just take a good bit of creativity from the defensive coaches.