Harrison is a beast in the middle, controlling him and not just leaving Witten to block Vernon will be big keys for the running game. Of course Dak is much better now than he was then and the Giants were clearly loading up against the run, I think Dak is better equipped to make them pay than he was in the first game.
As an aside, an interesting note about the Giants is that they obviously gave huge contracts to Vernon and Harrison over the offseason, but now the other half, the homegrown half of their DL in Hankins and JPP are free agents next year, and I doubt they'll be able to re-sign both, or even one of them considering their cap situation.
They basically went all in on their starting DL for one year, especially when you consider they have exactly 0 depth there.