It's not about comfort. It's about discrimination for the sake of discrimination. It's about people just now deciding their should be potty police, it's about sewing the seed that someone who appears trans might be a rapist. It's about people rolling out hysterics for the sake of harassing and marginalizing a group of people.
Listen I don't know what to tell you. Obviously there are big differences in the way cultural/ethnic/religious minorities encounter discrimination. Trans people don't have ancestral lands that can be stolen from them, also very rarely can people of other races pose as whites, etc. When I say unparalleled I wasn't minimizing the holocaust or wounded knee, to me that goes further than discrimination. But it's a fair point for you to say that Trans people haven't encountered that kind of large scale extermination (at least to my knowledge)
The point that I was making is they suffer a unique combination discriminations that I don't think any other minority experiences. Racial minorities don't get kicked out of their family for being racial minorities. Racial/Ethnic/Religious minorities have a community of support, trans people get put in much more isolated scenarios where they're rife for exploitation, abuse, and poverty. Again I'm not trying to minimize other kinds of discrimination just pointing out the unique challenges that only trans people face.